Chatterjee, Debabrata and Jaiswal, Namita and K., Jagadish C. Bose and Mahato, Ram Balak and Bhattacharyya, Diptendu (2015) Interaction of RuIII(EDTA) with cellular thiols and O2: biological implications thereof. Journal of Coordination Chemistry, 68 (17-18). pp. 3229-3235.

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Abstract

Reaction of [RuIII(EDTA)(CyS)]2− (edta4− = ethylenediaminetetraacetate; CySH = cysteine) with molecular oxygen (O2) has been studied as a function of pH (4.0–8.0) and cysteine concentration (0.2–2.0 mM) at room temperature (25 °C). Biological activities of the [Ru(EDTA)]/CySH/O2 system pertaining to cleavage of supercoiled plasmid DNA to its nicked open circular form has been explored in this work. Results are discussed in regard to the reaction of the ruthenium(III)-complex with molecular oxygen) and a working mechanism is proposed for the biological activities of the ruthenium(III)-complex in the presence of O2.

Item Type:	Article
Subjects:	Chemistry
Depositing User:	Dr. Sarita Ghosh
Date Deposited:	14 Sep 2016 07:02
Last Modified:	14 Sep 2016 07:02
URI:	http://cmeri.csircentral.net/id/eprint/235

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