Chatterjee, D. and Jaiswal, N. and Schmeisser, M. and van Eldik, R. (2014) Ru(III)(EDTA) mediated S-nitrosylation of cysteine by nitrite. Dalton Transactions, 43 (48). pp. 18042-18046.

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Abstract

Reported here is the first example of a ruthenium(iii) complex [Ru(III)(EDTA)(H2O)](-) (EDTA(4-) = ethylenediaminetetraacetate) that mediates S-nitrosylation of cysteine in the presence of nitrite at pH 4.5 (acetate buffer) and results in the formation of [Ru(III)(EDTA)(SNOCy)](-). The kinetics of the reaction was studied by stopped-flow and rapid-scan spectrophotometry as a function of [Cysteine], [NO2(-)] and pH (3.5-8.5). Formation of [Ru(III)(EDTA)(SNOCy)](-), the product of the S-nitrosylation reaction, was identified by ESI-MS experiments. A working mechanism in agreement with the spectroscopic and kinetic data is presented.

Item Type:	Article
Subjects:	Chemistry
Depositing User:	Dr. Sarita Ghosh
Date Deposited:	22 Sep 2016 11:17
Last Modified:	22 Sep 2016 11:17
URI:	http://cmeri.csircentral.net/id/eprint/336

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