Sarkar, Papiya and Saha, Amrita and Chatterjee, Debabrata (2016) [RuIII(EDTA)(H2O)]− catalyzed oxidation of biologically important thiols by H2O2. Journal of Coordination Chemistry, 69 (22). pp. 3417-3423.

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[RuIII(EDTA)(H2O)]− (EDTA4− = ethylenediaminetetraacetate) catalyzes oxidation of biological thiols, RSH (RSH  =  cysteine, glutathione, N-acetylcysteine, penicillamine) using H2O2 as precursor oxidant. The kinetics of the oxidation process were studied spectrophotometrically as a function of [RuIII(EDTA)(H2O)]−, [H2O2], [RSH], and pH (4–8). Spectral analyses and kinetic data are suggestive of a catalytic pathway in which the RSH reacts with [RuIII(EDTA)] catalyst complex to form [RuIII((EDTA)(SR)]2− intermediate species. In the subsequent reaction step the oxidant, H2O2, reacts directly with the coordinated S of the [RuIII((EDTA)(SR)]2− intermediate leading to formation of the disulfido (RSSR) oxidation product (identified by HPLC and ESI-MS studies) of thiols (RSH). Based on the experimental results, a working mechanism involving oxo-transfer from H2O2 to the coordinated thiols is proposed for the catalytic oxidation.

Item Type: Article
Subjects: Chemistry
Depositing User: Dr. Sarita Ghosh
Date Deposited: 09 Jun 2017 11:25
Last Modified: 09 Jun 2017 11:25

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