Chatterjee, M. and Hens, A. and Mahato, K. and Jaiswal, N. and Mahato, N. and Nagahanumaiah, Nagahanumaiah and Chanda , N. (2017) A novel approach to fabricate dye-encapsulated polymeric micro- and nanoparticles by thin film dewetting technique. J Colloid Interface Sci., 506. pp. 126-134.

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A new method is reported for fabrication of polymeric micro- and nanoparticles from an intermediate patterned surface originated by dewetting of a polymeric thin film. Poly (d, l-lactide-co-glycolide) or PLGA, a biocompatible polymer is used to develop a thin film over a clean glass substrate which dewets spontaneously in the micro-/nano-patterned surface of size range 50nm to 3.5µm. Since another water-soluble polymer, poly vinyl alcohol (PVA) is coated on the same glass substrate before PLGA thin film formation, developed micro-/nano-patterns are easily extracted in water in the form of micro- and nanoparticle mixture of size range 50nm to 3.0µm. This simplified method is also used to effectively encapsulate a dye molecule, rhodamine B inside the PLGA micro-/nanoparticles. The developed dye-encapsulated nanoparticles, PLGA-rhodamine are separated from the mixture and tested for in-vitro delivery application of external molecules inside human lung cancer cells. For the first time, the use of thin film dewetting technique is reported as a potential route for the synthesis of polymeric micro-/nanoparticles and effective encapsulation of external species therein.

Item Type: Article
Subjects: Polymers
Depositing User: Dr. Sarita Ghosh
Date Deposited: 08 Nov 2018 07:56
Last Modified: 08 Nov 2018 07:56

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