Ghosh, Pritam and Das, Joyee and Basak, Amit and Mukhopadhyay, Subhra Kanti and Banerjee, Priyabrata (2020) Intracellular Fluorometric Recognition of Explosive and Mutagenic Nitroaromatics by a Luminescent Phenanthrene-Naphthalene Sulfone. ChemistrySelect, 5 (28). pp. 8722-8728.

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Abstract

Novel phenanthrene-naphthalene sulfone based luminescent chemosensor has been synthesized for recognition of explosive and mutagenic 2,4,6-Trinitrophenolby fluorescence quenching with binding constant (1.93×105 M−1) and LOD (100 nM) that are better than reported sensory materials. Keeping in mind the toxic nature of 2,4,6-Trinitrophenol by, in vitro detection has been performed inside living organism like pollen cells of Tecoma Stans, Peperomia roots and Candida albicans. Luminescent phenanthrene-naphthalene sulfone has been synthesized having phenanthrene and naphthalene as antenna center with an aim of fluorogenic in vitro detection of highly mutagenic NACs, which are hitherto less explored. The chemosensor could detect NACs selectively over NALs of which TNP detection is highly selective by a swing in fluorescence spectrum from 405 to ∼475 nm with extremely high quenching constant 1.93×105 M−1 and LOD 100 nM. Fluorometric recognition of TNP was explained through a combined complex PET-RET-ACQ-CT pathway. DFT calculation has been performed to obtain the low energy configuration of the host⋅⋅⋅guest adduct. NMR titration reveals the chemical stability of the host in presence of TNP, suggests that the interaction belongs to supramolecular realm that supports the utilization of the chemosensor forin vitro detection of TNP within pollens of Tecoma Stans, Peperomia roots and Candida Albicans, indeed establishes the scaffold as a biocompatible chemosensor.

Item Type:	Article
Subjects:	Chemistry
Depositing User:	Dr. Arup Kr. Nandi
Date Deposited:	03 Nov 2022 10:18
Last Modified:	03 Nov 2022 10:18
URI:	http://cmeri.csircentral.net/id/eprint/750

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